Two new working arrangements will be signed in Brussels today between the EMCDDA and the European Chemicals Agency (ECHA) and the European Food Safety Authority (EFSA). The EMCDDA will now be cooperating with five EU agencies under new legislation applying from 23 November 2018, which strengthens the EU Early Warning System on new psychoactive substances (1). Three existing working arrangements with the European Centre for Disease Prevention and Control (ECDC); the European Medicines Agency (EMA) and Europol were updated and signed in December 2018 (2). 12.02.2019